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At just about every affected person visit, we measured the plasma HCV RNA degrees utilizing the Abbott RealTime HCV assay, which has a reported reduce limit of detection and quantification of 12 IU per milliliter. Samples with HCV RNA amounts underneath the decreased Restrict of detection or quantification ended up viewed as to possess undetectable ranges.

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Editor's Note: For good reasons of general public wellness, readers need to be mindful this letter has been “greatly and uncritically cited” as proof that dependancy is uncommon with opioid therapy. Leung et al. explain its background.

The research protocol (out there at NEJM.org) was created and formulated from the sponsor, Santaris Pharma, combined with the principal investigator at each research web site and Reps of Duke Medical Investigate Institute. All authors participated in the gathering of the info, experienced complete access to details, participated in the data Evaluation, and were involved in the planning and articles critique of the ultimate manuscript.

Each EIP web-site was questioned to recruit a total of nearly twenty five common and youngsters's acute care hospitals, with the following distribution according to measurement, if possible: thirteen tiny hospitals (

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Duke statisticians performed the statistical analyses. The publication committee, consisting of the initial writer and several coauthors (such as a agent of your sponsor), built the choice to submit the manuscript for publication. All authors vouch with the completeness and precision of this report along with the fidelity of the report to the research protocol.

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